Extrapolation of Carcinogenic Risk from Animal Experiments to Man
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چکیده
منابع مشابه
Extrapolation of carcinogenic risk from animal experiments in man.
When estimating the absolute risk of cancer, the shape of the dose--response curve in the region of doses where actual exposure of man occurs is of crucial importance. This shape is equally important for the determination of relative risks, as in the comparison of risks from alternative energy sources. Experimental and epidemiological studies are, for various reasons, unable to give sufficientl...
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Despite the above caveat, the impressive new technology described by Gupta et al1 in this issue of Circulation: Cardiovascular Imaging should help to resolve a number of issues relative to the hypothesis that the failing heart is energy starved and that depressed high-energy phosphate flux through the creatine kinase (CK) system is a causative factor.2,3 It will allow longitudinal measurements ...
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Conditions for extrapolating toxicologic data from animals to man were studied. In the search for general regularities associated with the comparative sensitivity of humans and various species of animals to toxins, it was shown that the toxicity parameters of compounds and the biological constants of mammals correlate with body weight. This relationship is well described by a rectilinear regres...
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Carcinogenic and Non-Carcinogenic Risk Assessment of Some Heavy Metals Due to Consumption of Raisin Produced in Malayer City Eisa solgi1*, Tarokh khodadadi2 1Associate Professor, Department of Environment, Faculty of Natural Resources and Environment, Malayer University 2Ph.D. Student of Environmental Pollution, Faculty of Natural Resources and Environment, Malayer University Abstract In...
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In 1999 Berry published a model for mesothelioma incidence following fiber exposure. He concluded, that the influence of the solubility of fibers on the mesothelioma rate is 17 times higher in humans than in rats. This conclusion may be helpful for evaluating the carcinogenic risk from man-made vitreous fibers, but it had little influence on some recent discussions. It has been demonstrated usi...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1978
ISSN: 0091-6765
DOI: 10.2307/3428545